2 Timothy 1:14
ESV - 14 By the Holy Spirit who dwells within us, guard the good deposit entrusted to you.
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In my opinion, the thought that Paul was expressing here was a caution to Timothy (and, by implication, to any Christian) against allowing the word of God as given in the Bible to be compromised or "watered down" by false teaching or belief that would be designed to make its interpretation or practice conform to or accommodate worldly (that is, sinful, fleshly, or carnal) principles, including the harboring of doubts about its truth, or disobedience to its commnands or requirements.
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