ESV - 17 No weapon that is fashioned against you shall succeed, and you shall confute every tongue that rises against you in judgment. This is the heritage of the servants of the Lord and their vindication from me, declares the Lord.
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Having the context for this verse in mind (previous chapters speak about how The Lord loves Israel and how The Lord would have mercy on them and gather them from every nation into the promise land), God is giving Israel a Promise, letting them know that, as long as they walk in God's commandments and statutes NO ONE will be able to prevent them from growing as a prosperous and mighty nation (as they are slowly doing at this very moment, as per the prophesy of the dry bones on Ezekiel 37), even under heavy resistance and surrounded of adversaries. The Lord of Hosts has said so, and so it is happening.
My opinion is that, "No weapon form against thee shall prosper" means nothing of evil shall defeat me. Even if I lose my life here on earth, I will regain it back through eternity for my love for God and the willingness to stand for righteousness in his name's sake. So pray for courage to overcome evil for good and fear not, for the Lord our God be with us! (As He promised)
I believe it means: no attack against your faith and integrity as a child of God can ever destroy you. Defend yourself against evil and trust in the Lord!
My opinion is that this passage refers to the spread of the Gospel to the Gentiles. The Jewish nation had not lived up to expectations that God had for them and had become as a barren nation; not producing and fruit because of their unfaithfulness. As a result they were overtaken and defeated by their enemies. Here God is declaring that all that has happened to them has not changed His love or promises to them but that he would fulfill His promise and add to it. The prophet Isaiah may not have understood the depth of the revelation of all that he wrote (by the inspiration of God). Again, the reference is about God's love for His chosen people and how their disobedience would make a way for the Gospel of salvation and redemption to be shared with all peoples.
The context of the verse is that God instructs, protects, and prospers Jerusalem's citizens (Isaiah 54:13-17): They have a just government, and their enemies stay far away. No weapon forged against you [,Jerusalem,] shall prosper [be successful]. Christ will prosper, be successful, and victorious over all foes (Isaiah 54:17; 52:13 margin, Isa. 53:10, and Jeremiah 23:5. The full realization of what is described for Israel in Isaiah 54:11-17 awaits the millennial era. This will be His coming exaltation.
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