Psalms 75:8 “For in the hand of the LORD there is a cup, and the wine is red; it is full of mixture; and he poureth out of the same: but the dregs thereof, all the wicked of the earth shall wring them out, and drink them.” King James Version (KJV)
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Multiple passages from Scripture (Psalm 104:15, for one example) speak of wine in a positive sense as a gift from God to man. However the dregs or lees are a bitter residual waste product from the wine-making process that sinks to the bottom of the vessel in which the wine is fermented, and are thus not healthy or intended to be consumed. Just as wine is viewed favorably, these dregs are metaphorically regarded in a negative sense (as in the verse cited in the question) as something that a person or nation would only be unwillingly forced to drink as a punishment for a sinful or negative action that the person or nation has performed.
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