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Although sex-change operations are not specifically mentioned in Scripture, human sexuality is spelled out clearly, starting in Genesis: "So God created people in his own image; God patterned them ...
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Psalm 139 is a very good piece of scripture to bring comfort to anyone who is struggling with any physical attribute. Perhaps some feel that God fell asleep while you were being formed in your mother's womb, that there was some sort of mistake made. Whether it was a physical disability, a feature that you don't like, or something about your sexuality, any of these things could make us uncomfortable about ourselves. The New Revised Standard Version, verse 13-16 says, 13 "For it was you who formed my inward parts; you knit me together in my mother’s womb. 14 I praise you, for I am fearfully and wonderfully made. Wonderful are your works; that I know very well. 15 My frame was not hidden from you, when I was being made in secret, intricately woven in the depths of the earth. 16 Your eyes beheld my unformed substance. In your book were written all the days that were formed for me, when none of them as yet existed." I love the concept of God sitting, knitting me in my mother's womb. He lovingly thought about every DNA stitch. Even the ones that I am not comfortable with, He planned them with care. His purposes for me are beyond my comprehension, so any area of my physical body that I am not comfortable with, He saw it before it existed, and rather than stressing about it, and trying to change it, He would prefer that I come into contentment with His plan for me. Verses 23-24 says: 23 "Search me, O God, and know my heart; test me and know my thoughts. 24 See if there is any wicked way in me, and lead me in the way everlasting" His way is peace and contentment in Him. So rather than changing your physical form, it would be best for your inner man to come to peace with God's plans for your life. May the Grace and Peace of the Lord Jesus Christ be upon you, settling your mind and bringing purpose and contentment to your life.
When someone decides to get a sex change, that person is saying, "God, you know what? You made a mistake." God NEVER makes mistakes! Don't do it!
A lot of people here have said God doesn't make mistakes and that is true. God creates us to be who we are, one of his children. But children are often mischievous or disobedient, but that doesn't make them less of a child of God. God doesn't cause us to sin, but allows the devil to put those temptations in front of us. People who say, "I was born in the wrong body" are denying that God made them who He wants to be. When they act on it, they have gone against His Word. I know of people who have said they were in the wrong body, or said they were born homosexual, and have gone on to lead Christian lives and not give in to the temptations. It's not wrong to identify with the.opposite sex, but it is sinful to act to present yourself as the opposite sex. They need our prayer and understanding. Remember that God hates the sin and not the sinner because we can all come boldly to the throne of grace and seek forgiveness.
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