ESV - 2 But your iniquities have made a separation between you and your God, and your sins have hidden his face from you so that he does not hear.
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Although humans regard some types of sin as being of a less heinous or egregious nature, or as having less spiritual significance, than others (which, to me, was what would have led to the development of the distinction between mortal and venial sin), the Bible (in my opinion) does not draw that same distinction. To me, the clearest indication of this is the statement made by James in his epistle (James 2:10) that if a person disobeys (or, as James puts it, "stumbles") with respect to just one point or requirement in God's Law, it makes that person as guilty in God's sight as if the person had disobeyed all of the Law's requirements. The apostle John spoke in his first epistle (1 John 5:16) about sins that lead to death, and sins that do not, but (as I understand it) he was speaking from a standpoint of the temporal consequences of those sins, rather than the spiritual or eternal consequences of them. (This would also be my response to the eBible.com question asking for an example of a mortal sin.)
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