Matthew 24:21
ESV - 21 For then there will be great tribulation, such as has not been from the beginning of the world until now, no, and never will be.
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To me, whatever specific catastrophic events might characterize that time, it is sufficient to know that, without God's ultimate direct intervention (such as removing the redeemed from the earth), there would be no life left. (Even in the devastation of the Flood, eight humans and pairs of animals were allowed to survive.)
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